ABSTRACT

Introduction 199 Mechanisms of action 200 Clinical effects of specific drugs 201 Pharmacokinetics and efficacy 202

Drug selection 203 Adverse effects 204 References 206

Pain has negative physical and psychological consequences in a growing body and mind. Recent evidence shows that the incidence and magnitude of troubled behaviour are negligible in children after surgery if they have proactive treatment with non-opioid analgesics as an adjunct to opioids [1].